The 1927 Ohio State game officially dedicated Michigan Stadium. The game program, with its cover rendering of the new facility, was, at 144 pages, the largest produced until 1983. The Wolverines, who could be depended on for a good game and a large crowd, played in stadium dedication games at Vanderbilt and Ohio State in 1922, Illinois in 1923 and Michigan State in 1948. Vanderbilt later played in a Michigan Stadium dedication game of sorts, the first game on artificial turf in 1969.

The Wolverines beat Ohio State 21-0 in the dedication game at Michigan Stadium. They had also handed the Buckeyes a 19-0 defeat in the Ohio Stadium dedication in 1922. Fielding Yost and his brother-in-law and former Michigan player Dan McGugin saw their teams play to a scoreless tie in the Vanderbilt stadium dedication game.

The Illini were not about to let Michigan spoil their dedication game in 1924. Red Grange scored touchdowns the first four times he touched the ball and racked up 297 total yards in the first quarter. Grange added another touchdown near the end of the game as Illinois rolled to a 39-14 win.

Michigan State dedicated Macklin Field in 1948 against the defending Rose Bowl and national champion Wolverines. Michigan opened the stadium with a 13-7 win enroute to another undefeated, national championship season. The Wolverines, however, would suffer three losses and a tie before winning another game at Macklin in 1964.